Why Some People Get High the First Time they Try Marijuana -- and Others Don't

Published Friday, May 19, 2017

Picture this: A group of friends, kicking back, watching the game.

The host presents an array of cannabis treats -- and a few guests decide to consume marijuana for the first time. By the night's end, some cannabis newbies are completely lit -- while other newbies remain unfazed.

It happens, but why?

That is, why do some people respond to cannabis consumption in different ways from others?

The short answer: Science!

You see, tetrahydrocannabinol, or THC, the compound in cannabis that causes a person to feel euphoria, or 'high', binds to cannabinoid receptors called CB1-receptors -- which are located in specific areas of the brain and central nervous system.

While some areas of the brain have high densities of these receptors -- the ability for THC to cause a 'high' relies, in part, on how many and how available the receptors are during cannabis consumption, according to a Learn Green Flower article.

Other factors in THC absorption include whether a person has compounds in their body which may conflict with THC's access to these receptors. (Conflicting compounds include some medications or psychoactive drugs.)

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Another reason, according to Dr. Ethan Russo, a cannabinoid scientist, is that exposure to THC may actually increase the effectiveness of cannabis over time -- imagine that!

"Lower doses of THC may jump-start the endocannabinoid system, which becomes more sensitive subsequently," Russo said in the same article.

Important Info for Cannabis Newbies

There are two main types of cannabis strains:

  • Indica strains cause relaxation and a 'body-high'
  • Sativa strains cause an energy boost and 'creative high'

Hybrid strains combine indicas with sativas. (Hybrids' effects vary depending on whether strains are indica-dominant, sativa-dominant or about equal crosses of both.)

Cannabis can be consumed in a variety of forms and each delivery method causes a different bodily reaction. For instance, smoked marijuana enters the lungs and enters into the nervous system within about 10 minutes or less.

Vaping cannabis is a form of consuming cannabis by inhaling and exhaling vapor from a liquid combination of chemicals (propylene glycol, vegetable glycerin or both) and natural or artificial flavors. Highs caused by vaping tend to be more brief and less intense compared to highs from smoking.

On the other hand, when cannabis is consumed in edible form, the strain is absorbed by the digestive system in a process that is much slower than when smoking, and the effects may not be felt for at least an hour.

Recommendations for Cannabis Newbies:

  • Research cannabis strains to determine your 'high' goals
  • Enjoy cannabis in small doses
  • Be patient, especially with edibles (which can take 1-2 hours for effects)

And, for reference, cannabidiol, or CBD, causes more a 'body high' and less of a psychoactive high.

We're happy to discuss our menu of cannabis options with you and can help you decide which strains may be best for your medical enjoyment. Of course, once you've placed an order, we'll discreetly deliver your cannabis to you -- even while you're watching the game.

 

 


 

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